ParkinsonCanadaV1, France, Analysis, bibRecord, 000303

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Identifieur interne : 000303 ( France/Analysis ); précédent : 000302; suivant : 000304

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Auteurs : M. Grandbois [Canada] ; M. Morissette [Canada] ; S. Callier [Canada, France] ; T. Di Paolo [Canada]

Source :

Neuroreport : (Oxford) [ 0959-4965 ] ; 2000.

RBID : Pascal:00-0365236

Descripteurs français

Pascal (Inist)
- Modèle animal, Parkinson maladie, Voie dopaminergique, Mâle, Estradiol, Encéphale, Animal, Souris, Souris C57BL/6.

English descriptors

KwdEn :
- Animal, Animal model, Brain (vertebrata), Dopaminergic pathway, Estradiol, Male, Mouse, Parkinson disease.

Abstract

The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p;, at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17β-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17α-estradiol (the isomer with weak estrogenic activity) has an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17β-estradiol, which is also observed with progesterone and raloxifene.

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Checkpoint: 000B68
to stream Main, to step Merge: 003B02
to stream Main, to step Curation: 003568
to stream Main, to step Exploration: 003568
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Links to Exploration step

Pascal:00-0365236

Le document en format XML

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<front><div type="abstract" xml:lang="en">The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p;, at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17β-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17α-estradiol (the isomer with weak estrogenic activity) has an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17β-estradiol, which is also observed with progesterone and raloxifene.</div>
</front>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri